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Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation

Artigas, MS (author)
Lind, Lars (author)
Uppsala universitet,Kardiovaskulär epidemiologi
Miller, S (author)
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Kheirallah, AK (author)
Huffman, JE (author)
Ntalla, I (author)
Shrine, N (author)
Obeidat, M (author)
Trochet, H (author)
McArdle, WL (author)
Alves, AC (author)
Hui, J (author)
Zhao, JH (author)
Joshi, PK (author)
Teumer, A (author)
Albrecht, E (author)
Imboden, M (author)
Rawal, R (author)
Lopez, LM (author)
Marten, J (author)
Enroth, Stefan (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Gyllensten
Surakka, I (author)
Polasek, O (author)
Lyytikainen, LP (author)
Granell, R (author)
Hysi, PG (author)
Flexeder, C (author)
Mahajan, A (author)
Beilby, J (author)
Bosse, Y (author)
Brandsma, CA (author)
Campbell, H (author)
Gieger, C (author)
Glaser, S (author)
Gonzalez, JR (author)
Grallert, H (author)
Hammond, CJ (author)
Harris, SE (author)
Hartikainen, AL (author)
Heliovaara, M (author)
Henderson, J (author)
Hocking, L (author)
Horikoshi, M (author)
Hutri-Kahonen, N (author)
Ingelsson, Erik (author)
Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi
Johansson, Åsa (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab,Uppsala kliniska forskningscentrum (UCR)
Kemp, JP (author)
Kolcic, I (author)
Kumar, A (author)
Lind, L (author)
Melen, E (author)
Karolinska Institutet
Musk, AW (author)
Navarro, P (author)
Nickle, DC (author)
Padmanabhan, S (author)
Raitakari, OT (author)
Ried, JS (author)
Ripatti, S (author)
Schulz, H (author)
Scott, RA (author)
Sin, DD (author)
Starr, JM (author)
Vinuela, A (author)
Volzke, H (author)
Wild, SH (author)
Wright, AF (author)
Zemunik, T (author)
Jarvis, DL (author)
Spector, TD (author)
Evans, DM (author)
Lehtimaki, T (author)
Vitart, V (author)
Kahonen, M (author)
Gyllensten, Ulf (author)
Uppsala universitet,Medicinsk genetik och genomik,Science for Life Laboratory, SciLifeLab
Rudan, I (author)
Deary, IJ (author)
Karrasch, S (author)
Probst-Hensch, NM (author)
Heinrich, J (author)
Stubbe, B (author)
Wilson, JF (author)
Wareham, NJ (author)
James, AL (author)
Morris, AP (author)
Jarvelin, MR (author)
Hayward, C (author)
Sayers, I (author)
Strachan, DP (author)
Hall, IP (author)
Tobin, MD (author)
Deloukas, P (author)
Hansell, AL (author)
Hubbard, R (author)
Jackson, VE (author)
Marchini, J (author)
Pavord, I (author)
Thomson, NC (author)
Zeggini, E (author)
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 (creator_code:org_t)
2015-12-04
2015
English.
In: Nature communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 8658-
  • Journal article (peer-reviewed)
Abstract Subject headings
Close  
  • Lung function measures are used in the diagnosis of chronic obstructive pulmonary disease. In 38,199 European ancestry individuals, we studied genome-wide association of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC) and FEV1/FVC with 1000 Genomes Project (phase 1)-imputed genotypes and followed up top associations in 54,550 Europeans. We identify 14 novel loci (P<5 × 10−8) in or near ENSA, RNU5F-1, KCNS3, AK097794, ASTN2, LHX3, CCDC91, TBX3, TRIP11, RIN3, TEKT5, LTBP4, MN1 and AP1S2, and two novel signals at known loci NPNT and GPR126, providing a basis for new understanding of the genetic determinants of these traits and pulmonary diseases in which they are altered.

Subject headings

NATURVETENSKAP  -- Biologi -- Genetik (hsv//swe)
NATURAL SCIENCES  -- Biological Sciences -- Genetics (hsv//eng)

Publication and Content Type

ref (subject category)
art (subject category)

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